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Latest San Francisco 49ers News

Tom Brady reveals story behind his beef with 49ers from 2000 NFL Draft

November 8th 2025

Tom Brady is still sour on the 49ers 25 years later. full article

Week 10 NFL odds, lines, best bets, predictions: Computer model likes Buccaneers and 49ers

November 8th 2025

SportsLine's advanced model has locked in its NFL bets today from 10,000 simulations full article

Rookie DT Sebastian Valdez elevated by 49ers, set to make NFL debut vs. Rams

November 8th 2025

The San Francisco 49ers on Saturday elevated rookie DT Sebastian Valdez and D-lineman Clelin Ferrell to face the Los Angeles Rams on Sunday. full article

NFL Week 10 Picks: 49ers Will Do Enough; Ravens, Chargers Roll

November 8th 2025

The NFC West may become clearer when the San Francisco 49ers go for a season sweep at home against L.A. Rams. Take Baltimore benind Jackson, the Chargers behind Herbert. full article

Week 10 NFL odds, picks, predictions: Our 10 NFL best bets, including a play in Rams-49ers

November 7th 2025

Our NFL handicappers give their best bets for Week 10 of the season. full article

NFL Week 10 bold predictions & key matchups: Maye vs. Mayfield, hoss fight NFC showdown, can 49ers survive the Rams?

November 6th 2025

Nate Tice & Charles McDonald dive into the Week 10 NFL slate with bold predictions, matchups to watch and more. full article

Rams vs 49ers Predictions, Picks & Best Bets for NFL Week 10

November 6th 2025

Our Rams vs. 49ers predictions expect a big game out of Puka Nacua in Week 10. full article

NFL Week 10 betting: Bucs, 49ers part of expert's top money line parlays for favorites and underdogs

November 5th 2025

SportsLine expert Jeff Hochman breaks down his top money line parlays for favorites and underdogs for Week 10 of the NFL season full article

Why it made no sense for 49ers to make blockbuster move at NFL trade deadline

November 5th 2025

Matt Maiocco makes sense of the San Francisco 49ers' inactivity on the final day before the NFL's 2025 trade deadline. full article

49ers made priorities clear with lack of activity at NFL trade deadline

November 4th 2025

The San Francisco 49ers didn't make any moves the day of the NFL trade deadline and confirmed their commitment to their team's future. full article

Fans overwhelmingly want 49ers to trade for one position before NFL deadline

November 3rd 2025

San Francisco 49ers fans hope the team prioritizes one position group over others before the 2025 NFL trade deadline. full article

Giants takeaways, report card from NFL Week 9 loss to 49ers

November 2nd 2025

Grading the Giants’ 34-24 loss to the 49ers on Sunday. full article

Giants vs. 49ers: Where to watch NFL Week 9, score prediction, promos, betting odds, SGP picks

November 2nd 2025

How to bet Giants vs. 49ers in the NFL Week 9 matchup on CBS and Paramount+ full article

Giants vs. 49ers, Vikings vs. Lions predictions: NFL Week 9 odds, picks

November 2nd 2025

Target these two Week 9 favorites. full article

Giants vs. 49ers prediction: NFL Week 9 odds, picks, best bets

November 2nd 2025

Another week, another top offensive weapon bit by the injury bug for Big Blue. This time around, rookie running back Cam Skattebo was the latest name to be added to the IR, as it’s been that type of season for the Giants. Jalen Hurts and Saquon Barkley dissec… full article